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Toxicity Testing Methods
Knowledge of toxicity is primarily obtained in three ways:
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|  | by the study and observation of people during normal use of a substance or from accidental exposures
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| | by experimental studies using animals
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| | by studies using cells (human, animal, plant)
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Most chemicals are now subject to stringent government requirements for safety testing before they can be marketed. This is especially true for pharmaceuticals, food additives, pesticides, and industrial chemicals.
Exposure of the public to inadequately tested drugs or environmental agents has resulted in several notable disasters. Examples include:
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| | severe toxicity from the use of arsenic to treat syphilis
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| | deaths from a solvent (ethylene glycol) used in sulfanilamide preparations (one of the first antibiotics)
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| | thousands of children born with severe birth defects resulting from pregnant women using thalidomide, an anti-nausea medicine
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By the mid-twentieth century, disasters were becoming commonplace with the increasing rate of development of new synthetic chemicals. Knowledge of potential toxicity was absent prior to exposures of the general public.
The following Federal regulatory agencies were established to assure public safety:
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| | Food and Drug Administration
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| for pharmaceuticals, food additives, and medical devices
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| | Environmental Protection Agency
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| for agricultural and industrial chemicals released to environment
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| | Consumer Product Safety Commission
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| for toxins present in consumer products
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| | Department of Transportation
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| for the shipment of toxic chemicals
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| | Occupational Safety and Health Administration
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| for exposure to chemicals in the workplace
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